Standard flagellin from S. typhimurium 100 µg

double filtration plasmapheresis (DFPP) in a 25-year-old female patient. Two months after the first DFPP treatment, a remarkable normalization of the clinical appearance was achieved. During the 3 years follow-up, the patient has had no detectable disease, and a sustained clinical remission has been maintained for 2 years after the interruption of therapy. DFPP therapy led to the complete regression of the severe disease. Therefore, we consider the therapy as promising for treatment of PsA.

Recombinant E. coli Flagellin Protein $ 88.00 – $ 1,618.00 Product Number Description Price QP8672-ec-10ug Size: 10 ug, Tag: GST $ 88.00 ADD TO CART QP8672-ec-50ug Size: 50 ug, Tag: GST $ 218.00 ADD TO CART QP8672-ec-100ug Size: 100 ug, Tag: GST $ 348.00 ADD TO CART QP8672-ec-200ug Size: 200 ug, Tag: GST $ 568.00 ADD TO CART QP8672-ec-500ug Size: 500 ug, Tag: GST $ 988.00 ADD TO CART QP8672-ec-1mg Size: 1 mg, Tag: GST $ 1,618.00 ADD TO CART

Recombinant E. coli Flagellin Protein $ 88.00 – $ 1,618.00 Product Number Description Price QP8672-ec-10ug Size: 10 ug, Tag: GST $ 88.00 ADD TO CART QP8672-ec-50ug Size: 50 ug, Tag: GST $ 218.00 ADD TO CART QP8672-ec-100ug Size: 100 ug, Tag: GST $ 348.00 ADD TO CART QP8672-ec-200ug Size: 200 ug, Tag: GST $ 568.00 ADD TO CART QP8672-ec-500ug Size: 500 ug, Tag: GST $ 988.00 ADD TO CART QP8672-ec-1mg Size: 1 mg, Tag: GST $ 1,618.00 ADD TO CART SHIPPING INFORMATION On Demand Protein: 3-5 Week Lead Time. (Why?) Flat Rate Shipping Anywhere in the US: $45

Recombinant E. coli Flagellin Protein $ 88.00 – $ 1,618.00 Product Number Description Price QP8672-ec-10ug Size: 10 ug, Tag: GST $ 88.00 ADD TO CART QP8672-ec-50ug Size: 50 ug, Tag: GST $ 218.00 ADD TO CART QP8672-ec-100ug Size: 100 ug, Tag: GST $ 348.00 ADD TO CART QP8672-ec-200ug Size: 200 ug, Tag: GST $ 568.00 ADD TO CART QP8672-ec-500ug Size: 500 ug, Tag: GST $ 988.00 ADD TO CART QP8672-ec-1mg Size: 1 mg, Tag: GST $ 1,618.00

Flagellin is the protein making up a flagellum, the appendage that bacteria use to move themselves around. As it happens, the presence of flagellae correlates decently well with harmful gut microbes, and the absence of flagellae correlates decently well with helpful gut microbes. In principle, provoking the immune system into greater efforts to chase down and destroy anything with a flagellum will better manage the microbial populations of the gut. These populations change with age in ways that promote chronic inflammation and reduce the generation of beneficial metabolites. Flagellin has been used in human clinical trials as an adjuvant to improve vaccination efficacy: it is recognized by the immune system, and helps produce a greater immune response. It was shown to have only minimal side effects in those trials. There is no human data for effects on the gut microbiome, but a very interesting paper describes the effects in mice. The outcome is a shifting of the relative population sizes of gut microbes in a beneficial direction that will reduce chronic inflammation. It is unknown as to how long such an effect might last - whether rousing the immune system is a short-term process, or whether it will continue to better guard against unwanted microbes.